암 면역치료의 이해 - Immunological Treatment of Cancer

1 암 면역시스템(Cancer Immune System)·································· 1
1-1 암 면역계··········································· 1
1-2 종양항원과 면역인지······································ 3
1-3 수지상세포(Dendritic cell)의 세포독성 T세포와 교차감작· ····················· 6
1-4 암 면역세포의 종양 내로의 이동································· 10
1-5 암 면역과 염증반응······································ 12
1-6 암 면역에서 호중구의 역할· ·································· 14
1-7 암 면역에서 NK세포의 역할··································· 15
1-8 암 면역에서 B세포의 역할· ·································· 17
1-9 암 면역에서 대식세포의 역할· ································· 20
1-10 면역내성(Immune Tolerance)· ·································· 23
2 암 면역시스템 검사(Test for Cancer Immune System)···························· 27
2-1 암조직에서 면역상태(Cancer Immunogram)의 검사· ························ 27
2-1-1 선천성면역(Innate Immune)의 검사···························· 28
2-1-2 획득면역(Adaptive Immune)검사······························ 29
2-1-3 선천성과 획득면역검사· ································ 30
2-2 암 미세환경(TME)의 면역상태(Immunity)에 대한 검사· ······················ 31
2-2-1 면역점수(Immunoscore) 검사· ······························ 31
2-2-2 암 미세환경의 면역검사 방법······························· 33
2-2-3 종양의 침윤림프구와 암의 예후······························ 40
2-2-4 면역관련 유전자의 특징에 따른 암의 예후························· 41
2-2-5 면역검사에서 유전체검사· ······························· 42
2-2-6 암조직의 계통면역학적(Cancer System Immunology) 검사방법················· 42
2-2-7 종양 미세환경의 면역상태에 의한 암의 분류························ 45
2-2-8 종양 미세환경에서 면역관문(Check point)검사· ······················ 47
2-2-9 종양 미세환경에서의 면역억제검사· ··························· 51
2-2-10 종양 미세환경에서의 암 줄기세포화(Stemness) 검사· ··················· 52
2-2-11 암의 미세환경에서의 전이관련 검사· ·························· 52
2-3 말초혈액에서 면역검사····································· 53
2-3-1 호중구와 림프구· ··································· 53
2-3-2 말초혈액에서 면역검사· ································ 53
2-3-3 말초혈액소견과 면역치료 효과· ····························· 54
2-3-4 액체생검(Liquid Biopsy)의 소견과 면역치료 효과· ····················· 54
2-3..